What is Zetia?
Action Zetia is based on the inhibition of absorption in the intestine nutritional cholesterol. Is used when patients are unable to tolerate other hypocholesteremic funds, or together with statins, when the latter do not give the desired effect.
Zetia 10 mg
Zetia operates in ciliary epithelium of a thin intestine, inhibiting absorption of cholesterol. He specifically associated with the key mediator of absorption of cholesterol protein-1. This protein is present in epithelial cells of gastrointestinal tract, and also in the hepatocytes. Reducing absorption of cholesterol under the influence of Zetia also adjusts the increase of capture in cells of LDL, with a lower level of cholesterol in blood plasma.
Zetia is used in hypercholesterolemia and in hereditary homozygous sitosterolemia.
Bioavailability Zetia is 35-65%, the drug is metabolized in gut and in liver, period of half-life is about 25 hours. Mainly excreted with excrement (78%), partially kidneys (11%).
Zetia 10 mg well tolerated. The most frequent Zetia side effects are headache and diarrhea.
Before you buy Zetia find out more about his contraindications:
- - in the appointment of Zetia in combination with statin to control contraindications to follow the instructions on the application of the appointed statin;
- - hypersensitivity to any component of Zetia;
- - patients with moderate and severe degree of renal insufficiency;
Zetia prescribed with caution:
- Patients already receiving cyclosporine.
Application of pregnancy and breastfeeding:
Studies in animals with the introduction of Zetia not reveal direct and indirect adverse effects with respect to pregnancy, development of the embryo/fetus, birth and post-Natal development.
Clinical data on use of Zetia in the period of pregnancy is not present. Therefore, use of the drug Zetia during pregnancy is not recommended. In the case of pregnancy the drug Zetia must be stopped.
In studies in rats have revealed that Zetia 10 mg is excreted in human milk. Data on the allocation of Zetia with breastfeeding women do not have. In connection with this Zetia 10 mg is not recommended for use in nursing mothers. If the use of medication is necessary, the patient should stop breastfeeding.
Zetia Side effects:
In clinical studies lasting from 8 to 14 weeks, in which was included 3366 patients, Zetia 10mg as monotherapy or in combination with statin, showed good tolerance.
Unwanted Zetia side effects were usually mild and transient; the total frequency of side-effects and the incidence of discontinuation of treatment due to adverse effects in the employment drug Zetia 10 mg did not differ from the indicators in the receiving placebo.
In patients taking Zetia 10 mg as in combination with statin or monotherapy, the most common (≥1/100, <1/10) were the following, associated with the product undesirable effects:
Monotherapy Zetia 10mg: headache, pain in the abdomen, diarrhoea.
Combination therapy with statin: headache, fatigue, pain in the abdomen, constipation, diarrhoea, bloating, nausea, myalgia.
Symptoms: it has been reported on several cases of overdose, most of which have not been accompanied by the emergence of undesirable phenomena, and in case of occurrence of adverse events were not serious.
In clinical studies, one in which Zetia 10mg appointed by the 15 healthy volunteers in the dosage of 50mg daily for 14 days, in the other – eighteen days patients with primary hypercholesterolemia in the dose of 40 mg per day for 56 days, was demonstrated good tolerance of the drug.
Treatment: symptomatic and supportive therapy.
Way of administration and dosage:
Inside, at any time of the day, irrespective of reception of food.
Before starting treatment, patients must go to the appropriate diet, which lowers lipids and continue to follow this diet during the whole period of the therapy Zetia 10mg.
The recommended dose of Zetia in in combination with statin or monotherapy is 10mg 1 time per day.
Selection of doses in elderly patients is not required.
When liver failure
Selection of doses for patients with mild hepatic impairment is not required. Treatment Zetia 10 mg is not recommended in patients with moderate and severe hepatic dysfunction.
In renal failure
Selection of doses to patients with impaired renal function is not required.
In related therapy sequestration fatty acids
Zetia should be taken in dose of 10mg 1 time per day no later than two hours before or not earlier than in 4 hours after the reception of the sequestration fatty acids.
Buy Zetia and follow the instructions:
Before starting treatment, patients should jump to the corresponding of hypolipidemic diet and continue to observe it within entire period of the therapy with the drug.
If you combined treatment with statin, then control of liver function should be undertaken at beginning of treatment, and then – in accordance with the recommendations for statin.
Clinical experience of the use of children and adolescents (aged nine to seventeen years) is limited to people with homozygous familial hypercholesterolemia and sitosteronemia.